Ulospora bilgramii
Ulospora bilgramii (D. Hawksw., C. Booth & Morgan-Jones) D. Hawksw., Malloch & Sivan., Can. J. Bot. 57(2): 96 (1979).
≡ Zopfia bilgramii D. Hawksw., C. Booth & Morgan-Jones, Mycol. Pap. 135: 10 (1974).
Index Fungorum number: IF 325237; Facesoffungi number: FoF 04645, Fig. 1
Description: see Doilom et al. (2018).
Material considered: see Doilom et al. (2018).
Fig. 1 Ulospora bilgramii (IMI 120811, holotype, re-illustrated from Doilom et al. 2018). a Herbarium label and specimen. b Appearance of ascomata on host surface. c Squash mount of ascoma. d Peridium. e–g Ascospores. Scale bars: b = 200 µm, c = 100 µm, d, e–g = 20 µm.
Importance and distribution
Industrial relevance and applications
Ulospora is significant to the medical industry as it produces Ulosporin G which inhibits the growth of human cancer cell lines and induces cell apoptosis through G0/G1 cell cycle arrest caused by DNA damage (Xie et al. 2020).
Biochemical importance of the genus, chemical diversity or applications
Ulospora produces a wide range of chemicals such as cytotoxic Heptaketides (Xie et al. 2020), (±)-Ulodione A, a pair of unprecedented cyclopentanones which have butyrylcholinesterase (BuChE) inhibitory activities (Luan et al. 2020) and other heptaketides such as one diphenyl compound, one spirobisnaphthalene, palmarumycin P5 (9), ulophenol (8), and ulosporin A–G. Ulospora possesses multiple biosynthetic pathways which yield secondary metabolites with novel structures (Luan et al. 2020). Ulospora comprises only one species known on Cassia siamea (Caesalpiniaceae) in Asia (India (Rajasthan)).
References
Doilom M, Hyde KD, Phookamsak R, Dai DQ et al. 2018 – Mycosphere Notes 225–274: types and other specimens of some genera of Ascomycota. Mycosphere 9, 647–754.
Luan XY, Xie F, Xu K, Gao Y et al. 2020 – (±)-Ulodione A, a pair of unprecedented cyclopentanones from Ulospora bilgramii. Tetrahedron Letters 61, 151732.
Xie F, Luan XY, Gao Y, Xu K, Lou HX. 2020 – Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii. Journal of Natural Products 83, 1623–1633.
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